This chapter addresses the question of how to prepare every child for the new global economy. It introduces the Framework for 21st century Learning developed by Partnership for 21st century Skills. It is a unified, collective vision for 21st century learning that can be used to strengthen American education. The key elements of 21st century learning are presented and described. This chapter also addresses how school districts might implement the framework. Self-assessment, professional development, collaboration with community, and high school reform are discussed as effective strategies.